Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous . Lúpus eritematoso sistêmico bolhoso – diagnóstico diferencial com dermatite herpetiforme. O lúpus eritematoso sistêmico pode apresentar inúmeras lesões cutâneas. As lesões bolhosas específi cas do lúpus, apesar de raras, apresentam. Systemic lupus erythematosus (SLE) can cause numerous skin lesions. Despite being rare, Lúpus eritematoso sistêmico bolhoso em gestante: relato de caso.

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Clinically, BSLE is characterized by a generalized vesiculobullous eruption, non-cicatricial, restricted to photo-exposed areas, or not.

Ultraviolet radiation, high anti-Ro antibody titers, deposition of immune complexes and abnormal cellular immunity are considered to be responsible for damage to the basal layer. PAS staining evidenced thickening of the basal membrane BM of the epidermis, more intense around the hair follicles Figure 2.

It has different clinical-pathological features. Dapsone can induce hypersensitivity syndrome with features similar to those for mononucleosis infection. The histopathological examination showed acanthosis, vacuolar degeneration of the basal cell layer, pigmentary incontinence, periadnexial mononuclear infiltrate, follicular plugging and comedones.

It is supposed that at least half of the patients with this condition have the tendency to develop systemic LE. Rio Branco, 39 Approved by the Advisory Board and accepted for publication on There was complete remission with dapsone, with no recurrence of skin lesions throughout one year of follow-up. Autoimmune blistering skin diseases. Patients may develop residual hyperpigmentation, and scars or milia may occasionally form. The patient remained stable during 1 year of follow-up.

A biopsy of the skin lesion was carried out, and the pathological findings included a subepidermal blister with neutrophilic microabscesses in the dermal papillae suggestive of dermatitis herpetiformis Figure 4.

Autoimmune Diseases

Histopathological examination reveals a subepidermal blister with neutrophilic microabscesses in the dermal papillae, perivascular inflammatory infiltrate composed of lymphomononuclear cells and, in some cases, leukocytoclastic vasculitis. Find articles by Luiz Carlos Takita. Tetracycline was suggested at the beginning of the treatment and an antinflammatory and immunoregulator agent that has been successful on the treatment of acneiform conditions.


With discontinuation of the tetracycline there was an acute recurrence of the lesions. It is important to remember that in both EBA and BSLE, anti-type VII collagen antibodies are present in the sublamina densa of the basement membrane zone and that both conditions luphs similar genetic characteristics as they are both associated with the HLA-DR2 antigen.

Comedonic lupus: a rare presentation of discoid lupus erythematosus

Paniker U, Levine N. Journal List An Bras Dermatol v. Adjuvant therapies must also be used in cases that do not respond to or are intolerant of dapsone; the use of azathioprine, antimalarial agents, mycophenolate lups and cyclophosphamide has been reported in the literature.

Report of two cases and a review of the literature.

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Bullous lesions in a patient with SLE leads to two important diagnoses: Services on Demand Journal. J Low Genit Tract Dis. The acneiform presentation of discoid CCLE is rare and only bollhoso cases have been reported so far.

Find articles by Nelise Ritter Hans-Bittner. Nelise Ritter Hans-Bittner 1 Dr. The treatment of choice is dapsone; the therapeutic response is usually satisfactory. Support Center Bokhoso Center.

The histological findings are comparable to those on the literature review, like: Treatment of autoimmune blistering diseases. Please review our privacy policy. Scar classification in cutaneous lupus erythematosus: Autoimmunity, Skin diseases, vesiculobullous, Lupus erythematosus, systemic. Bullous systemic lupus erythematosus: Int Soc Dermatol ; All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Pruritus may or may not be present.


We highlight the rarity, due to the fact that it developed during childhood, in a patient under standard SLE treatment. They preferentially affect the torso and supraclavicular region but may also affect the mucosae, particularly in the mouth and pharynx. The patient also presented with asthenia, occasional fever and a general decline in her health, as well as very large axillary and cervical lymph holhoso of 5 months duration.

We report a case of a year-old girl who presented with a vesiculobullous eruption on her face, neck, trunk and genital and oral mucosa, as well as anemia, volhoso pyuria, ANA 1: Author information Article notes Copyright and License information Luus.

The patient was then started on hydroxycloroquine mg daily with clinical improvement in 45 days Figure 4. Other less frequent side effects include neuropathy and bone marrow depression. The diagnosis of comedonic DLE was confirmed mainly by the histopathological changes.

Favre-Racouchot disease, also known as ‘cutaneous nodular elastoidosis with cysts and comedones’ is characterized by volumous open, black comedones, located on the sun damaged skin of the elderly. Histopatologia da pele de Lever. The main differential diagnoses of BSLE are acquired epidermolysis bullosa, dermatitis herpetiformis, bullous pemphigoid and linear IgA bullous dermatosis. Al-Refu K, Goodfield M. The case described here illustrates the typical signs and symptoms of bullous systemic lupus erythematosus and draws attention to the need for clinical and histopathological differential diagnosis with dermatitis herpetiformis.

BSLE is a rare disease that has an incidence of less than 0. During twelve months of follow-up no signs or symptoms of systemic disease were observed.