FARMACEVTSKA TEHNOLOGIJA PDF

Feature: for medium temperatures > °C or frequent changes in temperature. 0 to 1 bar – 0 to 60 bar relative, 0 to 1 bar – 0 to 25 bar absolute; Medium. HART® interface; Optional explosion protection [Ex ia] according to ATEX, GOST- R, DNV; Linearity %; Turn down: ; Simple operation with rotary knob. Get this from a library! Farmacevtska tehnologija. Del 1, Praktikum. [Julijana Kristl ; Jelka Šmid-Korbar; Stanko Srčič].

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Tlak | Farmacevtska tehnologija | Branže | JUMO

CFD simulations were performed in a 2D axisymmetric space using the two-fluid model. The effect of the Wurster gap and fluidizing air flow rate on gas-solidflow was farmscevtska in both simulations and experiments. Please enable JavaScript or use a modern browser. The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule sizeand size distribution, granule shape and flowability, as well as on drug release rate.

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Farmacevtska tehnologija: Praktikum. Del 1

Granule size was mainly influenced by binder particle size. Javascript is necessary for the proper functioning of this website. Please enable JavaScript or use a modern browser. You have to log in to leave a comment.

The results obtained indicate that conventional fluid bedgranulator may be suitable for production of highly spherical agglomerates,particularly when immersion and layering is dominant agglomeration mechanism.

Pellet coating is commonly performed in a fluid bed coater such as a Wurster coater.

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Binder content was shown to be important for narrow size distribution far,acevtska goodflow properties. A rather good agreement between the simulated and experimental results was observed and thus it can be assumeed that this particular simulation setup represents a computationally reasonable tool that provides a valuable insight into the Wurster coating process due to the impact of two-phase flow properties on the process.

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Computational fluid dynamics CFD simulations and experimental measurements of laboratory-scale Wurster coating were performed. Granule shape was affected by interplay of binder content, binder particle size and granulation time. URL – Presentation file, Visit http: Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate.

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Experimentally, the draft tube two-phase flow was evaluated by measuring the volume fraction of pellets within the draft tube and local particle velocities at the tube exit and by monitoring the local pressure drop fluctuations.

The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production. Voting is allowed only to logged in users. Hydrophilic polyetilenglycol and hydrophobic meltable binder glyceryl palmitostearate were used for in situ farmzcevtska hot melt granulation. Solid state analysis confirmed unaltered physical state of the granulate components and the absenceof interactions between the active and excipients.

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