Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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Koch Cotula cinereum Cotula coronopifolia L. The essential oil and the ethyl acetate extract showed moderate cytotoxic effects From This Paper Figures, tables, and topics from this paper. This was followed by the ethyl acetate extract and the essential oil with moderate effects against RD cell line and showed IC 50 values of The exact mechanisms through which such compounds act in their cytotoxicity effect are not well known, but some tentative investigations suggested that these compounds could interrupt the life cycle cell, inducing the apoptosis pathways and inactivating the telomerase [ 6 ].

Voucher specimens of both plants were deposited in the herbarium of the Botany Department of this institution.

Cotula cinerea

Furthermore, natural cotuls could be as efficient as synthetic ones with no or less toxicity and are less expensive than synthetic drugs.

In the same conditions, higher concentrations were needed in the case of Salvia verbenaca extracts. Since his account, only a few changes have been made but the number of species has remained more or less stable. Cell viability was evaluated by determination of the percentage of cytotoxicity using the formula given below.

Those of Salvia verbenaca were collected on March at the locality called Ain Aouda, in the Rabat region, Morocco. Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect. The enumeration of cells was made using Malassez cell count. For the town, see Cotula, Tennessee. Burtt Cotula reptans Benth. After 30 minutes of incubation at room temperature, absorbance was measured at nm using an ELISA plate reader.


Huile essentielle de Santolina africana Jord. icnerea

After filtration and cinerex of ethanol, the obtained aqueous solution was successively fractionated with hexane, ethyl acetate, and n -butanol.

Composition chimique et isolement des deux principaux constituants. Oils, Volatile Search for additional papers on this topic.

Cotula – Wikipedia

Levyns Cotula elongata B. Cotula is known to be used in New Cineea as ground cover for bowling greens, playing fields on which the ball-game of bowls is played [6] [7]. In this work we were interested in exploring the potential cytotoxicological effect of Cotula cinerea and Salvia verbenaca from Morocco. Examination of the cytotoxic activity of the Cotula cinerea individual compounds would give crucial information regarding the exact mechanism of this plant in antitumor activity. However, and despite the widespread use of these plants in Moroccan traditional folk medicine, to the best of our knowledge, no information has been previously reported on coyula anticancer activity cinerra Moroccan Cotula cinerea and Salvia verbenaca.

This study is expected to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further investigations on other types of cancer cell lines. The Royal Society of New Zealand. Articles with cinerrea microformats Commons category link is on Wikidata Taxonbars with 20—24 taxon IDs Taxonomy articles created by Polbot.

Cotula australis Sieber ex Spreng. Morocco is rich in medicinal plants on which some studies have been focused on antitumor activities [ 7 — 10 ].

Moreover, a molecule could have an effect on one type of tumor and not on others. Traditional forms of medicine, especially the herbal products deployed for centuries in many parts of the world, could be good alternative for scientific investigation due to their attributes against tumor cell lines. In the case of the RD cell line, the Cotula cinerea hexane extract showed the higher cytotoxic effect followed by the ethyl acetate, the essential cothla, and the n -butanol extract.

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In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Fotula verbenaca. A preliminary phytochemical screening of the Cotula cinerea and Salvia verbenaca extracts showed the presence of polyphenols such as flavonoids and other secondary metabolites.

To receive news and publication updates for BioMed Research International, enter your email address in the box below. The hexane, ethyl acetate, and n -butanol extraction yields were, respectively, 1.

Flavonoids from Cotula cinerea Del

View at Google Scholar F. Cotula cinerea which is of the Asteraceae family is a xerophytic plant widely distributed in sandy and desert grounds [ 11 ]. Antiproliferative activity at different concentrations of the essential oil and different extracts of Cotula cinerea top and Salvia verbenaca bottom against RD cell line by MTT assay.

Material and Methods 2. These plants are widely used in the Moroccan traditional folk medicine. Nevertheless, the Cotula cinerea essential oil can act through various mechanisms. The evaluation of cell viability has been achieved through the cinedea of MTT 3- finerea tetrazolium bromide assay. The obtained values are correlated with the metabolized intracellular MTT concentrations and ciinerea therefore proportional to the number of living cells.

Cotula vulgaris Levyns Cotula zeyheri Fenzl. These two species were obtained from the National Institute of Health, Rabat, Morocco, and were cultivated as previously described by Aneb et al. The three extracts hexane, ethyl acetate, and n-butanol of each plant in addition to the essential oil of Cotula cinerea have then been assayed for their cytotoxic activity against RD and Vero cell lines using MTT assay.

Exploring alternative sources of new antitumor agents with specific targets is thus imperative and of great cootula crucial importance.