Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.
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Nasopharyngeal angiofibroma – Wikipedia
For the growth and metastasis of solid tumors, angiogenic growth factors are essential. Estrogen receptors in nasopharyngeal angiofibromas. It accounts for 0. Juvenile nasopharyngeal angiofibroma originates in the sphenopalatine forame, causing epistaxes and nasal obstruction. The changes quantity in number of copies is higher then that of several malign naofaringeo, despite the JNA is histologically seen as a benign tumor.
Nasopharyngeal angiofibroma: Our experience and literature review
Several surgical approaches have been utilized for the removal of nasopharyngeal angiofibromas, including transnasal, transpalatal, transzygomatic, and transcervical accesses, in addition to lateral rhinotomy and mid-facial degloving, with or without extension to the upper lip or concomitant craniotomy 9.
Hasofaringeo higher density toward the periphery is noted, which was seen in the present case too. JNA’s sex selectivity and the relatively young age at diagnosis suggest that its development is hormone dependent. Maurice M, Milad M.
Pathogenisis of Juvenile Nasopharyngeal Fibroma A new concept. JNA being an aggressive tumor may recur posttreatment. The tumor is primarily excised by external or endoscopic approach.
Case 3 Case 3. Androgen receptor, juvenile angiofiborma, nasopharyngeal angiofibroma.
Gains and losses were detected in autosomal chromosomes and, more frequently, in sexual chromosomes 16,17, Unable to process the form. Supply of these tumours is usually via The volume of intraoperative bleeding has been shown to be similar in patients with and without embolization 34whereas tendency to relapse was greater in patients undergoing embolization. The main advantage of endoscopic surgery is the possibility of obtaining a broad view of the lesion and its anatomic relationship with adjacent structures, promoting more accurate, complete dissection and better control of bleeding 9,14, Nasal cavity, paranasal sinuses, nasopharynx Other tumors Nasopharyngeal angiofibroma Author: Accessed December 31st, Frequent b-catenin mutations in juvenile nasopharyngeal angiofibromas.
Surgical approaches for conventional techniques include transpalatal, transmaxillary, lateral rhinotomy, mid-facial degloving, extended sublabial Denker, and Le Fort type I osteotomy 11 13 20 Laterally, these tumors may extend to and fill the pterygomaxillary fossa, causing the posterior wall of the maxillary sinus to bulge and eroding the pterygoid plate.
Based on angikfibroma clinical and radiological features, JNA is classified into three types. The classic nasofaringro of epistaxis, unilateral nasal obstruction and a mass in the nasopharynx suggests the diagnosis of NAJ and is then supplemented by imaging.
Mast cells and T-lymphocytes in juvenile angiofibromas. Numerous growth factors seem to be implicated in the pathogenesis of tumor. Variables analyzed included patient age, sex, symptoms, tumor stage, treatment, duration of surgery, volume of intraoperative bleeding, need ahgiofibroma nasal packing after surgery, length nasofarjngeo hospitalization, immediate and late complications, recurrence, and preoperative embolization and clamping of the external carotid during surgery.
High levels of c-Kit CDa protein with tyrosine kinase action of the PDGFR platelets derivate growth factor receptors family, have already been related to other tumors.
This factor has a stimulatory action known over the endothelial, muscular and fibroblast cells, and is implied in the processes of tissue remodeling, apoptosis, healing, angiogenesis and in the tumor growth. For example, a retrospective study of 15 patients found tumor recurrence in 1 patient 6.
Endoscopic Surgery of Nasopharyngeal Angiofibroma
However, even partially, genetic and molecular factors may explain the tumor aggressive and angiogenic characteristic in addition to its sex-related selectivity. CT images show a heterodense mass that is centered in the sphenopalatine foramen. HUANG et al 25 show that the technique with two surgeons via the transseptal later shows less morbidity and lower rate of recurrence after resection of the tumor proper. Currently it is believed that the tumor has its origin in the posterolateral wall of the nasal cavity, where the sphenoid process of palatine bone meets the horizontal lamina of the vomer and part of the pterygoid process of sphenoid bone.